CHAVI: A Multi Center Acute HIV-1 Infection Prospective Observational Cohort StudyProject Focus
HIV/AIDS; Acute HIV; HIV Vaccines
Esselen Street Clinic, Hillbrow, Johannesburg
Duration of Project
2006 – 2010
Centre for HIV/AIDS Vaccine Immunology (CHAVI) - Duke University, University of North Carolina.
US National Institutes of Health (NIH), via CHAVI
Dr Vincent Okwuolise and Dr Claire von Mollendorf
Project Aims /Objectives
To collect biological specimens to study the HIV-1 virus, the host response, the genetic factors that determine HIV transmission and viral set point.
- To determine the prevalence of acute HIV infection at the participating sites;
- To determine the characteristics of the transmitted virus in acute HIV-1 infection;
- To determine the host acquired and inate immune responses that contribute to virus control and/or protection against infection with HIV-1;
- To determine genetic factors that contribute to early virus control and/or protection from infection;
- To examine the clinical, laboratory and behavioural characteristics of individuals at diverse sites with acute HIV infection and their sexual partners, and appropriate controls.
Recruit approximately 1300 participants internationally, (sites in Malawi, South Africa, Tanzania and USA), who are 18 years or older and will be enrolled into the study. Eligible participants will be placed into one of the following four study groups:
The study duration will be approximately 84 months with accrual requiring approximately 60 months. Each participant will be followed up for 24 months.
- Group 1 – Proven acute HIV-1 infection: approximately 600 in total
- Group 1a – Sexual partners of members of Group 1 : approximately 600 in total
- Group 2 – Established HIV-1 infection : approximately 50 total
- Group 3 – HIV-1 negative : approximately 50 total
Specimens collected during the study will be used to describe the immune response to HIV-1 and identify markers for HIV vaccine development.
- Contribution to protocol development
- Development of behavioral component protocol
- Site development
Further Acute HIV Infection & Vaccine development studies.
Projects in the STI's & HIV Research Cluster:
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