STI's and HIV Research 
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The STI/HIV Research Cluster’s objective is to develop clinical and non-clinical interventions for the prevention and treatment of STIs and HIV, and to deliver them to the communities that most need them.

To achieve this, the STI and HIV research team focus on evaluating the effectiveness of new or innovative strategies, (be they new treatments or new approaches using existing treatments), to prevent the acquisition, transmission or progression of HIV and other STIs.

STI's & HIV Research

Currently projects are undertaken in four specific areas of investigation

  • Microbicides
  • Treatment for Genital Herpes to Prevent HIV Transmission
  • Interventions to Increase Access and Use of Services by Higher Risk
  • Mobile Populations Interventions for Persons Newly Infected with HIV.
These activities are supported by a strong social medicine programme focusing on the social life and context of participants in the trials, as well as the communities where these participants are from.

The team consists of over 90 people, working from clinical trial sites in Soweto, Orange Farm, Yeoville and inner city Johannesburg, who are involved in the implementation of 8 community-based randomised controlled trials.

All these activities combine in a bid to find alternative ways of reducing new HIV infections.

For enquiries specific to the STI's and HIV Research Cluster, please email [email protected]

  A Multi Center Acute HIV-1 Infection Prospective Observational Cohort Study
  DfiD Research Programme Consortium: Consortium for Research and Capacity Building in Reproductive and Sexual Health and HIV/AIDS in developing countries
  A Safety & Acceptability Study of a Vaginal Ring Microbicide Delivery Method for the Prevention of HIV Infection in Women (IPM011)
  Acute HIV infection (AHI) identification
  Contraceptive Research Planning Survey: Comparison of DEPO-PROVERA and IUD Pilot Study
  A phase III randomized, double blind, placebo controlled trial of acyclovir for the reduction of HIV acquisition among high risk HSV2+ HIV- individuals (HPTN039) (known locally as Thembalethu)
  Sub-study to an international multi-centre, randomised, double-blind, placebo-controlled trial to evaluate the efficacy and safety of 0.5% and 2% PRO 2000/5 gels for the prevention of vaginally acquired HPV infection
  A multi-centred randomised trial of therapeutic intervention at primary HIV-1 infection (also known as SPARTAC)
  An international multi-centre, randomised, double-blind, placebo-controlled trial to evaluate the efficacy and safety of 0.5% and 2% PRO 2000/5 gels for the prevention of vaginally acquired HIV infection
  National Research Foundation Thuthuka Programme: Developing & Advancing Excellence in Researchers
  The Safety and feasibility study of the diaphragm used with Acidform gel or KY Jelly
  Evaluation of quadrivalent HPV vaccine in reducing the incidence of anogenital warts and related genital infection in young men
  IPM Microbicide Feasibility Study
  STI/HIV Research Adherence
  STI/HIV Research HSV2 Shedding
  STI/HIV Research Gates PIP
  Focus on Men: A Programme to Improve Male Involvement in Sexual & Reproductive Health (known locally as Mpilonhle-Mpilonde)