HPV Vaccine Study

• Recruitment, screening & enrolment of 24 participants.
• Vaccination and post-vaccination follow-up for safety and efficacy for three years.
• Regular ongoing HIV testing of participants

• Vaccine - induced serum antibody responses to HPV 6, 11, 16, 18
• Safety of dose regimen of quadrivalent HPV vaccine
• Incidence of HPV related anogenital warts
• Incidence of HPV 6, 11, 16, 18 detection/infection

Additional Outputs

• Condom use and sexual risk behaviour in young men

Future Plans

• none
  

Projects in the STI's & HIV Research Cluster:

• A Multi Center Acute HIV-1 Infection Prospective Observational Cohort Study
• DfiD Research Programme Consortium: Consortium for Research and Capacity Building in Reproductive and Sexual Health and HIV/AIDS in developing countries
• A Safety & Acceptability Study of a Vaginal Ring Microbicide Delivery Method for the Prevention of HIV Infection in Women (IPM011)
• Acute HIV infection (AHI) identification
• Contraceptive Research Planning Survey: Comparison of DEPO-PROVERA and IUD Pilot Study
• A phase III randomized, double blind, placebo controlled trial of acyclovir for the reduction of HIV acquisition among high risk HSV2+ HIV- individuals (HPTN039) (known locally as Thembalethu)
• Sub-study to an international multi-centre, randomised, double-blind, placebo-controlled trial to evaluate the efficacy and safety of 0.5% and 2% PRO 2000/5 gels for the prevention of vaginally acquired HPV infection
• A multi-centred randomised trial of therapeutic intervention at primary HIV-1 infection (also known as SPARTAC)
• An international multi-centre, randomised, double-blind, placebo-controlled trial to evaluate the efficacy and safety of 0.5% and 2% PRO 2000/5 gels for the prevention of vaginally acquired HIV infection
• National Research Foundation Thuthuka Programme: Developing & Advancing Excellence in Researchers
• The Safety and feasibility study of the diaphragm used with Acidform gel or KY Jelly
• Evaluation of quadrivalent HPV vaccine in reducing the incidence of anogenital warts and related genital infection in young men
• IPM Microbicide Feasibility Study
• STI/HIV Research Adherence
• STI/HIV Research HSV2 Shedding
• STI/HIV Research Gates PIP
• Focus on Men: A Programme to Improve Male Involvement in Sexual & Reproductive Health (known locally as Mpilonhle-Mpilonde)